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- Erythrocytosis has been reported as a potential effect of testosterone, which can be beneficial in sufferers with anemia.
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- Supplemental or physiologic doses of testosterone have seen expanded use in medical practice lately.
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However, testosterone in physiologic doses might even be useful in sufferers with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in men with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s danger profile as nicely as the testosterone dosing may be issues of whether adverse events occur. Erythrocytosis has been reported as a potential impact of testosterone, which could be beneficial in patients with anemia.
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients should pay attention to the scientific penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
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Patients additionally may be taking concomitant stimulants, such as ephedra, which might confound data and the potential for antagonistic occasions. It is in all probability going that the frequency of cardiac events is underreported within the medical literature. Moreover, testosterone has been used in the therapy of reduced muscle mass and bone density as well as anemia. The position testosterone could play in the growth of heart problems has more and more turn into the topic of present interest . Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and artificial derivatives of testosterone, may cause a large spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical apply lately. Other widespread potential opposed results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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